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Generic Aldactone (Spironolactone) is used as a diuretic to remove the excess fluid caused by congestive heart failure, cirrhosis of the liver, and kidney disease. It can also be used to treat elevated blood pressure in combination with other drugs and in resistant cases of low potassium. Generic Aldactone may be also used to counteract the effects of excessive adrenal aldosterone production.

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How Taken

Generic Aldactone comes as a tablet to take by mouth. It usually is taken once a day in the morning with breakfast or twice a day with breakfast and lunch. Usual dose 50-100 mg/day, which for difficult or severe cases may be gradually increased at 2-weekly intervals up to 200 mg/day. The daily dose may be given either in divided doses or as a single daily dose. When Spironolactone is added to the regimen, its dosage should first be reduced by at least 50%.

Spironolactone description

Spironolactone is an aldosterone antagonist. Spironolactone influences the body's own hormone, aldosterone, which accelerates the excretion of potassium and reduces the excretion of sodium and water Simplified, aldosterone regulates the endogenous water household. The higher the aldosterone level, the more water is stored in the body. The use of results in a significant reduction in the aldosterone level so that an increased excretion of sodium and water occurs while, at the same time, potassium is reabsorbed.

Possible Side Effects

Continue to take Spironolactone and talk to your doctor if you experience unusual headache or dizziness; nausea, diarrhea, or a decrease in appetite; dry mouth; bloating; muscle cramps; or lowering of the voice, excessive hair growth, or enlarged breasts.

Drug Interactions

Spironolactone reduces the vascular responsiveness to norepinephrine. Lithium generally should not be given with diuretics. Rarely, instances of hyponatremia, hyperkalemia, or hepatic coma may occur in patients with severe liver disease, but these are unlikely due to acute overdosage. In some patients, the administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effect of loop, potassium-sparing and thiazide diuretics.