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Celebrex is the first of Cox-2 inhibitors - traditional anti-inflammatory drugs target general prostaglandin production, affecting both Cox-1 and Cox-2 enzymes.
Celecoxib or Generic Celebrex reduces pain and inflammation with little stomach irritation.
Celebrex was developed and introduced by Pharmacia, a drug company that no longer exists.
Unlike the older medications, Celecoxib does not interfere with a substance called COX-1, which exerts a protective effect on the lining of the stomach.
Generic Celebrex
Celecoxib 100/200mg
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Celecoxib uses
Celecoxib is also used to decrease growths found in the intestines (colon polyps) of persons with a family history of this condition. Read the Medication Guide provided by your pharmacist before you start using celecoxib and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist. Take by mouth, usually once or twice daily, or as directed by your doctor. To decrease the chance of stomach upset, this drug is best taken with food. Dosage is based on your medical condition and response to therapy. The lowest effective dosage should always be used, and only for the prescribed length of time (see also Warning section).
Adverse Reactions Which Occur Rarely
The most commonly occurring (greater than 5%) adverse events in celecoxib treated patients were headache, fever (pyrexia), upper abdominal pain, cough, nasopharyngitis, abdominal pain, nausea, arthralgia, diarrhea and vomiting. A total of 378 patients were treated with Celebrex in placebo- and active- controlled ankylosing spondylitis studies. The types of adverse events in the analgesia and dysmenorrhea studies were similar to those reported in arthritis studies. Celecoxib metabolism is predominantly mediated via cytochrome P450 2C9 in the liver. Co-administration of celecoxib with drugs that are known to inhibit 2C9 should be done with caution.
Celebrex Drug Interactions
In a study conducted in healthy subjects, mean steady-state lithium plasma levels increased approximately 17% in subjects receiving lithium 450 mg BID with Celebrex 200 mg BID as compared to subjects receiving lithium alone. Doses up to 2400 mg/day for up to 10 days in 12 patients did not result in serious toxicity. Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare.
